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Teratogenic potential of antiepileptic drugs: need for research, patient education

May 25, 2016

…0:e0131130; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4492893/pdf/pone.0131130.pdf). The estimated risk of congenital malformations with valproic acid is 2-7 times higher than with other antiepileptic drugs (Tanoshima et al. Clin Pharmacol Ther 2015;98:417-441). Other agents with teratogenic potential include lamotrigine, carbamazepine, ethosuximide, fosphenytoin, phenobarbital, phenytoin, primidone, and topiramate. In addition, a pro…

AAN 2016 DAILY REPORT

April 21, 2016

…f interferon therapy; 14.5% had SPMS. ARR was significantly lower with the combination compared to interferon monotherapy (0.12 vs. 0.32). There was also a benefit with the combination in RRMS/active SPMS patients with respect to MRI measures of disease activity (Gd+ lesions, active T2 lesions, combined unique active lesions). Secondary-progressive MS: An international study interviewed 16 clinicians about how they diagnosed SPMS (Ziemssen et al….

Growing evidence of traumatic brain injury as a PD risk factor

April 13, 2016

…6, and followed-up to 2011 (Gardner et al. Ann Neurol 2015;77:987-995). Outcomes were compared to patients with non-TBI trauma, such as fractures. Overall, older TBI patients were more likely to be diagnosed with PD over the next 5-7 years compared to non-TBI trauma patients (1.7% vs. 1.1%; adjusted HR 1.44). PD risk was similar in patients with TBI due to a fall compared to other TBI causes. PD risk was higher following moderate/severe TBI compar…

Off-target effects proposed as reason for phase I study death

April 6, 2016

…own vasomotor effects that might be compatible with some of the lesions observed in the affected subjects. The TSSC investigation is ongoing and the committee plans to produce comprehensive good-practice recommendations on first-in-man trials. For a free download of the TSSC minutes, 07 March 2016: English: http://ansm.sante.fr/content/download/86439/1089765/version/1/file/CR_CSST-FAAH_15-02-2016_Version-Anglaise.pdf French: http://ansm.sante.fr/c…

Radiological biomarker proposed for PD

March 30, 2016

…te nucleus was found in advanced-stage PD patients. Similar results were seen in a longitudinal study that used R2* imaging (Ulla et al. PLoS One 2013;8:e57904; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3585727/pdf/pone.0057904.pdf). Over a three-year period, R2* increased in the SN and putamen in PD patients but not in controls. Variation in R2* was significantly correlated with worsening motor symptoms. Reviewer: Dr. Susan Fox…