Off-target effects proposed as reason for phase I study death


Off-target drug effects may be the reason for the phase I accident in France that left one person dead and five others hospitalized (see 1 dead in phase I trial, NeuroSens, January 27, 2016). However, other causes are also being explored by the 12-person Temporary Specialist Scientific Committee (TSSC) set up by France’s Agence national de securité du medicament et des produits du santé (ANSM).

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