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Novel CSF biomarkers being investigated in AD

August 10, 2016

…et al. JAMA Neurol 2015;72:1029-1042). Amyloid PET imaging with Pittsburgh compound was also obtained. Beta-amyloid42 showed an inconsistent pattern over time, although some subjects showed reductions in beta-amyloid42; low levels were associated with the development of cortical amyloid plaques. VILIP-1 and other markers of neuronal injury (total tau, p-tau181) showed marked increases in some individuals in mid-to-late middle-age, whereas the neur…

Opioid use increasing in elderly patients with dementia

July 13, 2016

…s to manage neuropsychiatric symptoms as an alternative to antipsychotics. Comment Dr. Catherine Brodeur: These results help us to keep in mind that almost every medication has side effects and that it is mandatory – especially in a geriatric population – to assess the risks and benefits of each drug. This careful analysis must be done by appropriately diagnosing the patient’s conditions and by taking into account the comorbidities of the patient…

APA highlights: Treatment trials in psychiatry

June 22, 2016

…ith clonazepam versus paroxetine. Re-initiation of treatment was generally successful in patients who relapsed. Back to top Schizophrenia Phase II and III results: ITI-007 is a novel compound in development for schizophrenia. The agent is a 5HT-2A receptor antagonist, a dopamine D2 receptor modulator (pre-synaptic partial agonist, post-synaptic antagonist), a 5HT reuptake inhibitor and a glutamate GluN2B receptor modulator (Davis et al. Expert Rev…

RBC distribution width useful in differential diagnosis of stroke

June 15, 2016

…d Cancer Study found that the incidences of total stroke and cerebral infarction were higher in individuals with high RDW values (Soderholm et al. PLoS One 2015;10:e0124957; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4423855/pdf/pone.0124957.pdf). Comparing the highest versus lowest quartile of RDW values, the adjusted hazard ratios for total stroke and cerebral infarction were 1.31 and 1.32, respectively. There was no significant asso…

Relevance of assessing body weight in MS patients

June 8, 2016

…ublished February 25, 2016). There were four PML cases with monthly dosing compared to 0 with extended dosing, although additional data are needed to determine if extended dosing will lower PML risk. Comment Dr. François Grand’Maison: There is no doubt that BMI should be taken into consideration in the treatment of MS. Catherine Larochelle from the CHUM in Montréal wrote the following in our report of IFNβ-treated patients who developed thrombotic…