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Iatrogenic Alzheimer’s – is AD transmissible?

November 9, 2016

…on-to-person contact. (For a podcast of researcher Dr. John Collinge go to www.nature.com/nature/podcast/index-2016-03-17.html). Then earlier this year, a second study found similar findings (Frontzek et al. Swiss Med Weekly; free full text at www.smw.ch/content/smw-2016-14287/). The autopsy study examined seven subjects who died of iatrogenic CJD after dural grafting. Over 200 CJD deaths have been reported following dural grafts obtained from cad…

ECTRIMS 2016 SLIDE DECK

October 24, 2016

…ermissions are required prior to use. But as a courtesy, we would like to ask that you provide us with feedback after your presentation(s). This will help us to fine-tune free educational resources that NeuroSens develops in the future. Click here to complete the feedback questionnaire…

Phase III results for siponimod in SPMS

September 28, 2016

…;4:333-337; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4027137/pdf/ml300396r.pdf). Dosing is titrated, which attenuates the first-dose bradycardia associated with S1P modulation (Legangneux et al. Br J Clin Pharmacol 2013;75:831-841). Dosing and safety were previously examined in the phase II BOLD trial (Selmaj et al. Lancet Neurol 2013;12:756-767; Kappos et al. JAMA Neurol 2016;73:1089-1098). In the EXPAND trial, subjects were enrolle…

ECTRIMS DAILY REPORT – FRIDAY EDITION

September 16, 2016

…Y trial (Giovannoni et al. N Engl J Med 2010;362:416-26; free full text at www.nejm.org/doi/pdf/10.1056/NEJMoa0902533); and the phase II ONWARD trial of cladribine as an add-on to IFN-beta-1a (Montalban et al. AAN 2016; abstract 3285). For the CLARITY extension, after a median treatment interruption of 41 weeks, patients initially randomized to cladribine 3.5 or 5.25 mg/kg were randomized to 3.5 mg/kg or placebo; and the placebo cohort was switche…

EMD Serono’s LAUNCH program – A model for academia/industry partnerships

September 7, 2016

…that would meet an unmet need and serve as a contribution to the neurology community. We’d already established success with these types of programs in reproductive endocrinology and dermatology. After an extensive needs analysis, we discovered that there was a strong need in neurology as well.” Involving industry in educational programs can be problematic, as shown by the increasingly stringent requirements for these collaborations that many acade…