Radiological biomarker proposed for PD


A number of studies in patients with Parkinson’s disease have reported increased iron concentrations in brain structures, notably the substantia nigra (SN), which may be prognostic of disease severity. One method for assessing iron deposition is to determine the relaxation rate (R2*, the sum of R2 and R2’) on MRI, in which inhomogeneities in the magnetic field due to iron deposition result in a more rapid signal decay and an increase in the relaxation rates.

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