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Zika virus – New guidelines for managing pregnant women

February 3, 2016

…miting. Symptoms generally persist for up to one week. Severe disease is uncommon. Co-infection with dengue virus has been described (Dupont-Rouzeyrol et al. Emerg Infect Dis 2015;21:381-382). A case of Zika virus infection complicated by Guillain-Barre syndrome has also been reported (Oehler et al. Euro Surveill 2014;19. pii: 20720). Back to top Zika virus and pregnancy The CDC reports that pregnant women can be infected with Zika virus in any tr…

Increased cardiovascular risk in Parkinson’s disease

December 16, 2015

…sk of ischemic stroke in PD patients (Huang et al. PLoS One 2013;8:e68314; free full text at www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023710/). The study compared 2,204 PD patients and the same number of propensity score-matched subjects. At three-year follow-up, there were 328 ischemic strokes in the PD group compared to 156 strokes in the non-PD group (HR 2.37). It is unclear why PD patients have an increased risk of MI and stroke and further st…

High-efficacy MAbs in MS: an update

November 25, 2015

…ab, treatment was ineffective in slowing disability unrelated to relapses (www.businesswire.com/news/home/20151021005273/en/Biogen-Reports-Top-Line-Results-Phase-3-Study). For the Canadian cohort of TOP (n=339), ARR declined from 1.68 at baseline to 0.19 after a mean of 2.4 years (Bhan et al. ECTRIMS 2015; abstract EP1333). EDSS scores remained stable from baseline (3.5) to year 3 (3.1). The incidence of serious adverse events was 8.3%, most commo…

Depression in PD often untreated despite improved detection

November 18, 2015

…014; epublished July 17, 2014; free full text at http://iospress.metapress.com/content/92617284j0410402/fulltext.pdf). The study was part of the NPF’s Quality Improvement Initiative. The analysis included data for 7,031 patients collected prospectively from movement disorder centres in North America; average age was 58 years and mean duration of illness was 8.9 years. The emotional domain of the Parkinson’s Disease Questionnaire (PDQ-39) was used…

New data on first-line oral therapies in MS

November 4, 2015

…s severe in a patient with a previous history of drug-induced hair loss. A complete or near-complete resolution or marked improvement in hair thinning was reported by 79% of patients at follow-up. The time to hair regrowth was not reported. Overall, 1 of 38 patients permanently discontinued teriflunomide and one patient interrupted treatment due to hair thinning. DMF: An emerging safety issue is progressive multifocal leukoencephalopathy (PML) fol…