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Sleep disorder in PD: a role for circadian rhythm disturbance?

August 6, 2014

…eta-analysis of modafinil found that there was insufficient evidence for recommending the drug for PD patients with excessive daytime sleepiness (Sheng et al. PLoS One 2013;8:e81802; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3849275/pdf/pone.0081802.pdf). A novel suggestion is that disturbances to circadian rhythm may play a role in sleep-wake disturbances in PD. To investigate this, a cross-sectional study monitored serum melatonin l…

APA 2014: New Research – Part 1

June 25, 2014

…7.2% with vortioxetine 15 mg and 20 mg versus 15.8% with placebo. The most common adverse effects were nausea, headache, diarrhea, dry mouth, dizziness and excessive sweating. A second 8-week study comparing vortioxetine 15 mg or 20 mg/day with duloxetine 60 mg/day or placebo in 614 MDD patients reported similar results (Mahableshwarkar et al. APA 2014; NR9-01). The least-squares mean change from baseline in MADRS total score was -14.30 and -15.57…

MS patient website tops 70,000 visits

June 3, 2014

…s in MS research, and to refer their MS patients to MSology to learn more about their disease. To access the site, go to www.MSology.com….

Facebook: friend or foe of psychiatry?

May 14, 2014

…4X-13-268.pdf). Reins et al. BMC Psychiatry 2013;13:318, free full text at www.biomedcentral.com/content/pdf/1471-244X-13-318.pdf). The latest alternative to face time is Facebook. A new study has examined whether joining Facebook – and specifically “friending” the psychiatrist – is beneficial in patients with treatment-resistant depression (Mota Pereira J. Scientific World J 2014;2014:892048; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PM…

The high impact of neurological and psychiatric disorders: the Global Burden of Disease Study

May 14, 2014

…s major depression (Charlson et al. BMC Med 2013;11:250; free full text at www.biomedcentral.com/content/pdf/1741-7015-11-250.pdf). Depressive disorders are the leading contributor to disability-adjusted life years (DALY), and the second-leading cause of YLD (Ferrari et al. PLoS Med 2013;10:e1001547; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3818162/pdf/pmed.1001547.pdf). The greatest burden is seen in depressive disorders, followed b…