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Traumatic brain injury in sports a focus of annual meeting

May 2, 2014

…ofessional athletes. A review of the hockey literature found that the most common CNS injuries were concussion (0.2-6.6 per 1000 player-hours), and spinal cord injuries (5.0 per 1000 player-hours) (Toy et al. AAN 2014; abstract P5.343). An analysis of blood biomarkers in 28 Swedish Hockey League players reported that levels of total-tau (T-tau, a marker of axonal injury) and S100 calcium binding B (S-100B, a marker of astroglial injury) were eleva…

Alemtuzumab receives Health Canada approval

April 23, 2014

…monitoring for autoimmune thyroid disease is advised. Alemtuzumab is not recommended in women planning to become pregnant or during breastfeeding. Approval of alemtuzumab (Lemtrada) was based on the results of two phase III studies (CARE-MS I, CARE-MS II) and a phase II study (CAMMS223). In CARE-MS I, alemtuzumab and subcutaneous interferon-beta-1a 44 mcg three times/week were compared in 563 treatment-naïve RRMS patients (Cohen et al. Lancet 2012…

Fingolimod: impact on beta-amyloid neurotoxicity?

March 19, 2014

…elination (Miron et al. Am J Pathol 2010;176:2682-2694). Other non-immunological effects of fingolimod in the CNS may include downregulation of S1P1 signalling from astrocytes, which reduces astrogliosis and clinical severity in EAE (Choi et al. PNAS USA 2011;108:751-756; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3021041/pdf/pnas.201014154.pdf) For a recent review of S1P1 signalling in the CNS see Groves et al. J Neurol Sci 2013;328:9…

MS treatment failure: who is at risk?

March 19, 2014

…elapses, sphincteric symptoms, multifocal symptoms, relapse severity and incomplete recovery (Bergamaschi et al. J Neurol Sci 2001;189:13-21; Leone et al. Mult Scler 2008;14:485-493). Relapse frequency also has had prognostic significance in some studies (Hirst et al. J Neurol 2008;255:280-287). However, the UBC group found that although one or more relapses in the first five years post-diagnosis was important, the number of relapses became less i…

Neurodegenerative disease and high-voltage power lines

March 5, 2014

…sulted in inconsistent conclusions. A decade ago, an international panel recommended a multinational study with more rigorous data collection to investigate the possible association of EMF exposure and neurological diseases (Kheifets et al. Occup Environ Med 2009;66:72-80). A Canadian review concluded that there is little evidence of health effects with EMF exposure (Habash et al. Crit Rev Biomed Eng 2003;31:141-195). The same authors also reviewe…