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Catherine is a 30-year-old woman who presents following her first neurological episode. She developed numbness and paraesthesias involving her right leg and lower trunk six weeks ago. Symptoms evolved over several days but remained mild. She continued working throughout the episode and did not require corticosteroid treatment. Her symptoms resolved completely over approximately two weeks. She is otherwise healthy, takes no regular medications and has no history of recurrent or serious infections. Read More

Click here to watch Dr. Jiwon Oh discuss the case and your responses to the quick poll.

Ellen is a 48-year-old elementary teacher with a history of migraine dating back to her twenties. She is perimenopausal with hot flashes and fatigue, and a recent increase in migraine frequency to 5-6 headaches per month. Her family physician diagnosed depression two years ago and started Ellen on a trial of sertraline. Read More

Click here to watch Dr. Virginia Devonshire discuss the case and your responses to the quick poll.

Michael P. is a 55-year-old male diagnosed with relapsing MS five years ago. He presented with a spinal cord relapse that resulted in residual sensory and mild bladder dysfunction in his lower limbs and EDSS 2.5. His MRI had a thoracic lesion and more than 10 brain lesions meeting McDonald 2017 criteria. He was started on teriflunomide 14 mg/day but reported poor tolerability. Read More

Click here to watch Dr. Caitlin Jackson-Tarlton discuss the case and your responses to the quick poll.

P.B. is a 57-year-old woman with a 24-year history of relapsing-remitting multiple sclerosis.  She was treated with an injectable from 2002-2012. Her last relapse was in 2009. She was transitioned to fingolimod in 2012 because of ongoing MRI changes and increasing tolerability issues. Read More