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Epstein-Barr and MS: meta-analysis

March 5, 2014

…hree anti-EBV antibodies: anti-EBV nuclear antigen 1 (anti-EBNA-1) or EBNA complex; antiviral capsid antigen (anti-VCA); and anti-Early Antigen (anti-EA). The median seroprevalence of anti-EBNA IgG was 98% in MS patients compared to 88% in controls (odds ratio 4.7). The median anti-VCA IgG seropositivity was 99% in MS patients versus 92% in controls (OR 4.51). In contrast, the median seroprevalence for anti-EA IgG was similar in cases and controls…

Depression and discrimination: the ASPEN/INDIGO study

February 19, 2014

…(Kohn et al. Bull World Health Organ 2004; 82: 858-866; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2623050/pdf/15640922.pdf). Comment Drs. Arun Ravindran and Nisha Ravindran: The last three decades have seen significant growth in the literature on psychiatric stigma. This recent publication, the result of a large collaborative European study focusing on patients with major depression, reports findings that are notable but not unexpect…

Subthalamic stimulation useful for early motor complications

February 19, 2014

…cal therapy with respect to motor disability, ADLs, levodopa-induced motor complications, and time to good mobility and no dyskinesia. Serious adverse events occurred in 54.8% with stimulation/medical therapy and 44.1% with medical therapy alone. Serious adverse events relating to surgery or the device occurred in 17.7% of patients in the DBS group. Comment Dr. Michel Panisset: This is a well-designed and -conducted study. It reproduced what a sma…

MS treatment: What is Plan B?

December 5, 2013

…-diagnosis, when treatments may have their greatest impact on long-term outcomes in RRMS. Comment: Dr. Paul Giacomini, MD, FRCPC, Associate Director, MS Clinic, Montreal Neurological Hospital and Institute, Assistant Professor, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec: The advent of new oral therapies, coupled with a greater understanding of MS pathophysiology, is certainly reshaping the way neurologists and th…

Seizure prophylaxis following traumatic brain injury

November 13, 2013

…Trauma Foundation. J Neurotrauma 2007;24(suppl 1); free full supplement at www.braintrauma.org/pdf/protected/Guidelines_Management_2007w_bookmarks.pdf). A review of antiepileptics for TBI recommends phenytoin since it has been most extensively studied (Torbic et al. Am J Health Syst Pharm 2013;70:759-766). Other agents (e.g. phenobarbital, valproate, carbamazepine) have not been researched to the same degree and are not generally preferred over ph…