…n humans (Kleinewietfeld et al. Nature 2013;496:518-522; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3746493/pdf/nihms500370.pdf). This effect is specific to Th17, with little or no effect on Th1 or Th2 differentiation or proliferation. Moreover, salt-induced Th17 cells demonstrate increased production of pro-inflammatory cytokines, such as TNF-alpha and IL-2. A new study reports that higher salt consumption is associated with increased…
…g, 75 mg or 150 mg) or placebo for 36 weeks (Kappos 2014). Ninety patients completed the week 36 visit prior to early termination of the study. Atacicept reduced the number of mature B cells and serum Ig levels. However, the annualized relapse rate was higher in all three treatment groups (25 mg, 0.86; 75 mg, 0.79; 150 mg, 0.98) compared to placebo (0.38). The time to first relapse was also significantly shorter with atacicept 150 mg versus placeb…
…tion and emotions (Heller et al. Aging Dis 2013;5:63-75; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3901615/pdf/ad-5-1-63.pdf). Overall, cognitive dysfunction appeared to be more common in males, although the authors noted that test results are inconsistent. Males with PD were less accurate than females in identifying fearful expression, which is the opposite of what is found in healthy subjects. Women generally reported poorer quality…
…l. Transl Neurosci 2013;4:10.2478; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3873720/). They further noted that ELISA kits for amyloid-beta1-42 (and for t-tau) produced by different manufacturers will not have the same results and should not be used interchangeably. Comment Dr. Yves Bacher: Biomarkers will probably become more and more useful in the case of early-onset dementia, strong familial history, MCI management and atypical pre…
…zation of LAI continues despite the recently published Canadian Clinical Recommendations on LAI use, recommending that LAIs be positioned earlier in the course of treatment (Malla et al. Can J Psychiatry 2013). There are multiple reasons for the underutilization of LAIs. Some are patient-related, such as suspicion about injected drugs, concerns about a lack of personal control, etc. Some are clinician-related, such as a lack of staff support, the…