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Relapse prevention in first-episode schizophrenia: role of long-acting injectables

January 14, 2015

…Clin Psychiatry 2014; epublished August 19, 2014; free full text at http://www.psychiatrist.com/jcp/article/Pages/2014/v75n11/v75n1107.aspx [requires registration]). A total of 304 patients were randomized to aripiprazole OM 400 mg or placebo for 12 weeks. All subjects received concomitant oral aripiprazole 10-20 mg/day for 14 days. A significant treatment effect was seen at week 1, and this benefit was maintained at all time points throughout the…

Serotonergic mechanisms in PD: two reports

December 10, 2014

…sis were randomized to pimavanserin 40 mg/day or placebo for six weeks. Concomitant antipsychotic use was not permitted. The primary outcome was change from baseline in the PD-adapted Scale for Assessment of Positive Symptoms (SAPS-PD). Pimavanserin was associated with a greater decrease in SAPS-PD scores compared to placebo (-5.79 vs. -2.73). Pimavanserin was generally well tolerated. Sleep was also improved with the drug. Ten of 95 patients (10….

Future uncertain for active immunotherapies in AD – Part 1

December 10, 2014

…ounced in July 2014 in subjects at risk of developing AD (media release at www.novartis.com/newsroom/media-releases/en/2014/1824651.shtml). To date, BACE1 inhibitors have had a mixed track record. A phase II trial of LY2886721 was terminated due to hepatotoxicity, although it is unclear if liver effects were related to its anti-BACE effects (Lahiri et al. Alzheimers Dement 2014;10(5 Suppl):S411-419). Development of RG7129 has been stopped. However…

Poor adherence to migraine prophylaxis

October 8, 2014

…% for propranolol, 55% for amitriptyline, and 57% for topiramate. The most common reason for treatment discontinuation was adverse effects. A previous study of patient preferences reported that adverse effects commonly associated with discontinuation of migraine prophylactic drugs were cognitive effects (topiramate), somnolence (propranolol, amitriptyline) and weight gain (divalproex) (Kowacs et al. Headache 2009;49:1022-1027). Comment Dr. Daniel…

Combining drug and psychotherapy more effective for depression, anxiety

September 24, 2014

…ent evidence with respect to dysthymia, PTSD and GAD. The dropout rate was comparable with combined treatment and drug treatment alone. In examining either therapy alone and combined treatment versus placebo, the analysis found that the effects of psychotherapy and pharmacotherapy were largely independent of one another, with each contributing about 50% of the total treatment effect. Thus, there appears to be an additive benefit when a combination…