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West Nile virus: the season is upon us

May 22, 2013

West Nile virus (WNV) is an RNA viral pathogen of the Flaviviridae family that is genetically related to CNS viral pathogens such as dengue, yellow fever, Japanese encephalitis and tick-borne encephalitis. The virus is maintained in the bird population and transmitted through a mosquito vector. When first described in 1940 (Smithburn et al. Am J Trop Med Hyg 1940;1:471-492) in a patient in Uganda, WNV infection produced a mild fever. But the viru…

Web-based CBT effective for depression, QOL

May 8, 2013

…ate to high psychological distress were randomized to an Internet CBT program, weekly telephone follow-ups, Internet CBT plus weekly telephone follow-up, or usual care (Farrer et al. PLoS One 2011;6:e28099; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3227639/pdf/pone.0028099.pdf). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

Effect of walking on cognitive function in Alzheimer’s disease

April 24, 2013

…that sedentary patients show significant deterioration in MMSE total score compared to more active patients, and that walking on a regular basis appears to stabilize cognitive decline (Winchester et al. Arch Gerontol Geriatr 2013;56:96-103). A total of 104 AD patients were followed over a 12-month period and categorized as Active or Sedentary based on Yale Physical Activity Survey scores. Subscribe to read more It takes 30 seconds or login using y…

Uric acid and Parkinson’s disease

April 10, 2013

…further metabolized to allantoin by urate oxidase. In humans, a mutation to the UOx gene early in our evolution resulteprogred in an absence of functioning urate oxidase. In consequence, UA levels are as much as 10-fold higher in humans compared to other species (Alvarez-Lario & Macarron-Vicente. Rheumatology 2010;49:2010-2015). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you re…

Lower zolpidem dosing advised

April 10, 2013

The U.S. FDA has issued an advisory recommending a lower dose for products containing the hypnotic zolpidem, such as Ambien, Ambien CR, Edluar, and Zolpimist. In Canada, zolpidem is sold under the trade name Sublinox. Dosing for Intermezzo, a zolpidem formulation for middle-of-the-night awakening, is unaffected. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the news…