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Predictive value of NEDA and brain atrophy in MS

October 9, 2015

…ty had a significantly higher rate of subcortical grey-matter (GM) atrophy compared to healthy controls. Also important to long-term outcomes is the rate of brain volume loss, which is significantly higher in MS patients compared to age-matched controls. Accordingly, several authors have suggested a combined metric of NEDA + atrophy (NEDA-4) for predicting disability progression. The proposed cut-off value for percent brain volume change (PBVC) is…

ACTH revisited: melanocortins and MS

June 11, 2015

…he theoretical potential benefits of ACTH are reflected in new studies, the availability of a depot preparation could have practical delivery advantages in the community in comparison to IVMP. NeuroSens Survey This poll is currently disabled. Back to top…

Raising urate levels in Parkinson’s disease: the SURE-PD study

May 13, 2015

…Study (Weisskopf et al. Am J Epidemiol 2007;166:561-567; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2391073/pdf/nihms44448.pdf; Gao et al. Am J Epidemiol 2008;167:831-838; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2367211/pdf/nihms-44283.pdf). These findings were supported by the observation of a lower PD risk in patients with gout (De Vera et al. Arthritis Rheum 2008;59:1549-1554, free full text at http://onlinelibrary.wi…

From Framingham to Facebook: the contagion of controversy

April 1, 2015

…RB) approval (Kramer et al. PNAS USA 2014;111:8788-8790; free full text at www.pnas.org/content/111/24/8788.full.pdf). Facebook has argued that users agree to the company’s data use policy when they sign up, which constitutes informed consent. Cornell has stated that its IRB ruled that the project was not subject to the university’s Human Research Protection Program. PNAS USA normally adheres to the Health and Human Services Policy for the Protect…

Optimizing patient assessment in MS: NEDA and beyond

March 12, 2015

…study has examined the value of NEDA in predicting long-term disability outcomes. In a seven-year follow-up of patients in the Comprehensive Longitudinal Investigation of MS at the Brigham and Women’s Hospital (CLIMB) study, the positive predictive value (PPV) of NEDA for no significant progression (defined as EDSS change < 0.5) was 71.7% at one year, and 78.3% at two years (Rotstein et al. ECTRIMS 2014; abstract P763). The PPV was improved somewh…