The treatment of early-age mania (TEAM) trial randomized 279 treatment-naïve children and adolescents (6-16 years, mean 10.1 years) with bipolar I disorder (manic or mixed phase) to one of three anti-mania medications to assess their comparative effectiveness (Geller et al. Arch Gen Psychiatry 2012;epublished January 2, 2012)
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IFN-beta in CIS: phase III REFLEX results
May 2, 2012The higher dose of interferon-beta-1a (Rebif; 44 mcg) appears to effective in patients with clinically isolated syndrome (CIS) suggestive of MS, according to the results of the phase III REFLEX trial (Comi et al. Lancet Neurol 2012;11:33-41).
Treatment of motor symptoms of PD: MDS recommendations
April 11, 2012The Movement Disorder Society has presented new recommendations on the treatment of motor symptoms of Parkinson’s disease (Fox et al. Mov Disord 2011;26:S2-S41). The evidence-based review updates recommendations published in 2002 and 2004 (Goetz et al. Mov Disord 2002;17[suppl 4]:S1-S166; Goetz et al. Mov Disord 2005;20:523-539).
Inhaled ergotamine for migraine: phase III results
April 11, 2012MAP0004, a novel inhaled dihydroergotamine, is effective in the acute management of migraine, according to the results of the phase III FREEDOM-301 study (Aurora et al. Headache 2011; 51:507-517).