A 3-point change in the Alzheimer’s Disease Assessment Scale-Cognitive (ADAS-cog) score appears to be the minimal clinically relevant change for patients with mild Alzheimer’s disease (Schrag et al. J Neurol Neurosurg Psychiatry 2012;83:171-173).
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Oral anti-alpha4-integrin in development
March 14, 2012Firategrast, an oral formulation of a natalizumab-like small molecule, produces a significant reduction in MRI lesions, according to the results of a phase II study (Miller et al. Lancet Neurol 2012; epublished January 5, 2012).
Nicotine produces benefits in MCI
March 14, 2012Administration of transdermal nicotine improves cognitive performance in patients with mild cognitive impairment (MCI), according to the results of a pilot study (Newhouse et al. Neurology 2012;78:91-101).
Crossing your legs a favourable prognostic marker post-stroke
March 14, 2012A prospective, observational study in Germany reports that patients who cross their legs during a hospital stay for severe stroke have improved outcomes (Remi et al. Neurology 2011; 77:1453-1456).