Highlights of the 29th Congress of the European Committee for Treatment and Research in MS (ECTRIMS), Copenhagen, DK, October 2-5, 2013 – Recent treatment optimization recommendations have emphasized the importance of monitoring both clinical (relapses, EDSS progression) and radiological (T2 or T1 lesions) changes when assessing treatment response (Freedman et al. Can J Neurol Sci 2013;40: 307-323).