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Opioid use increasing in elderly patients with dementia

July 13, 2016

…s to manage neuropsychiatric symptoms as an alternative to antipsychotics. Comment Dr. Catherine Brodeur: These results help us to keep in mind that almost every medication has side effects and that it is mandatory – especially in a geriatric population – to assess the risks and benefits of each drug. This careful analysis must be done by appropriately diagnosing the patient’s conditions and by taking into account the comorbidities of the patient…

RBC distribution width useful in differential diagnosis of stroke

June 15, 2016

…specificity 99%, positive predictive value 92.8). An analysis of data from the Malmo Diet and Cancer Study found that the incidences of total stroke and cerebral infarction were higher in individuals with high RDW values (Soderholm et al. PLoS One 2015;10:e0124957; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4423855/pdf/pone.0124957.pdf). Comparing the highest versus lowest quartile of RDW values, the adjusted hazard ratios for total s…

Teratogenic potential of antiepileptic drugs: need for research, patient education

May 25, 2016

…logy clinic (Bhakta et al. Epilepsy Behav 2015;52(Pt A):212-217). The most common antiepileptic drugs used were topiramate and carbamazepine. Only 26% of patients had a documented method of contraception. Among contraception users, 60% were taking a combined hormonal or progestin-only pill, a majority of which had a potential for drug-drug interactions. A total of 7% of patients received counselling about a contraception plan, and 18% received cou…

Growing evidence of traumatic brain injury as a PD risk factor

April 13, 2016

…6, and followed-up to 2011 (Gardner et al. Ann Neurol 2015;77:987-995). Outcomes were compared to patients with non-TBI trauma, such as fractures. Overall, older TBI patients were more likely to be diagnosed with PD over the next 5-7 years compared to non-TBI trauma patients (1.7% vs. 1.1%; adjusted HR 1.44). PD risk was similar in patients with TBI due to a fall compared to other TBI causes. PD risk was higher following moderate/severe TBI compar…

Radiological biomarker proposed for PD

March 30, 2016

…ficantly higher in the SN, putamen and caudate nucleus of de novo patients compared to controls, suggesting iron overload at disease onset. R2* values in the SN were higher still in early-stage patients. Significant atrophy of the putamen and caudate nucleus was found in advanced-stage PD patients. Similar results were seen in a longitudinal study that used R2* imaging (Ulla et al. PLoS One 2013;8:e57904; free full text at www.ncbi.nlm.nih.gov/pmc…