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Growing evidence of traumatic brain injury as a PD risk factor

April 13, 2016

…6, and followed-up to 2011 (Gardner et al. Ann Neurol 2015;77:987-995). Outcomes were compared to patients with non-TBI trauma, such as fractures. Overall, older TBI patients were more likely to be diagnosed with PD over the next 5-7 years compared to non-TBI trauma patients (1.7% vs. 1.1%; adjusted HR 1.44). PD risk was similar in patients with TBI due to a fall compared to other TBI causes. PD risk was higher following moderate/severe TBI compar…

Radiological biomarker proposed for PD

March 30, 2016

…ficantly higher in the SN, putamen and caudate nucleus of de novo patients compared to controls, suggesting iron overload at disease onset. R2* values in the SN were higher still in early-stage patients. Significant atrophy of the putamen and caudate nucleus was found in advanced-stage PD patients. Similar results were seen in a longitudinal study that used R2* imaging (Ulla et al. PLoS One 2013;8:e57904; free full text at www.ncbi.nlm.nih.gov/pmc…

Increased cardiovascular risk in Parkinson’s disease

December 16, 2015

…oke in PD patients (Huang et al. PLoS One 2013;8:e68314; free full text at www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023710/). The study compared 2,204 PD patients and the same number of propensity score-matched subjects. At three-year follow-up, there were 328 ischemic strokes in the PD group compared to 156 strokes in the non-PD group (HR 2.37). It is unclear why PD patients have an increased risk of MI and stroke and further study is needed to e…

High-efficacy MAbs in MS: an update

November 25, 2015

…ab, treatment was ineffective in slowing disability unrelated to relapses (www.businesswire.com/news/home/20151021005273/en/Biogen-Reports-Top-Line-Results-Phase-3-Study). For the Canadian cohort of TOP (n=339), ARR declined from 1.68 at baseline to 0.19 after a mean of 2.4 years (Bhan et al. ECTRIMS 2015; abstract EP1333). EDSS scores remained stable from baseline (3.5) to year 3 (3.1). The incidence of serious adverse events was 8.3%, most commo…

Depression in PD often untreated despite improved detection

November 18, 2015

…kely to be treated or that current therapies are only partially effective. Comment Dr. Susan Fox: This large multicentre study shows that depression is common in PD. The importance of this report is that the evidence was gathered from patients and caregivers, not physicians, and shows a disconnect between the two. Physicians need to ask about depression at every visit. Treating PD depression can be challenging due to concerns about side effects of…