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Novel CSF biomarkers being investigated in AD

August 10, 2016

…ll text at www.ncbi.nlm.nih.gov/pmc/articles/pmid/25867677/). Results were compared to those for tau, p-tau181 and beta-amyloid42 in CSF. CSF and MRI were obtained over a 2-3 year follow-up. Mean age was 72.6 years. VILIP-1, tau and p-tau181 at baseline were comparably predictive of subsequent whole-brain and regional atrophy. Beta-amyloid42 was not useful as an atrophy biomarker. VILIP-1 was predictive of whole-brain, hippocampal and entorhinal a…

Opioid use increasing in elderly patients with dementia

July 13, 2016

…s to manage neuropsychiatric symptoms as an alternative to antipsychotics. Comment Dr. Catherine Brodeur: These results help us to keep in mind that almost every medication has side effects and that it is mandatory – especially in a geriatric population – to assess the risks and benefits of each drug. This careful analysis must be done by appropriately diagnosing the patient’s conditions and by taking into account the comorbidities of the patient…

RBC distribution width useful in differential diagnosis of stroke

June 15, 2016

…specificity 99%, positive predictive value 92.8). An analysis of data from the Malmo Diet and Cancer Study found that the incidences of total stroke and cerebral infarction were higher in individuals with high RDW values (Soderholm et al. PLoS One 2015;10:e0124957; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4423855/pdf/pone.0124957.pdf). Comparing the highest versus lowest quartile of RDW values, the adjusted hazard ratios for total s…

Teratogenic potential of antiepileptic drugs: need for research, patient education

May 25, 2016

…logy clinic (Bhakta et al. Epilepsy Behav 2015;52(Pt A):212-217). The most common antiepileptic drugs used were topiramate and carbamazepine. Only 26% of patients had a documented method of contraception. Among contraception users, 60% were taking a combined hormonal or progestin-only pill, a majority of which had a potential for drug-drug interactions. A total of 7% of patients received counselling about a contraception plan, and 18% received cou…

AAN 2016 DAILY REPORT

April 21, 2016

…f interferon therapy; 14.5% had SPMS. ARR was significantly lower with the combination compared to interferon monotherapy (0.12 vs. 0.32). There was also a benefit with the combination in RRMS/active SPMS patients with respect to MRI measures of disease activity (Gd+ lesions, active T2 lesions, combined unique active lesions). Secondary-progressive MS: An international study interviewed 16 clinicians about how they diagnosed SPMS (Ziemssen et al….