…dose of ocrelizumab. Ocrelizumab was excreted in breast milk in animal studies and women are advised not to breastfeed during treatment. Click on the link to download the Canadian Product Monograph: www.rochecanada.com//content/dam/roche_canada/en_CA/documents/Research/ClinicalTrialsForms/Products/ConsumerInformation/MonographsandPublicAdvisories/Ocrevus/OCREVUS_PM_E.pdf…
…fingolimod (Carpenter et al. Mult Scler 2017;23:297-299). Management is becoming more complicated as neurologists are increasingly faced with sequential treatment choices, with the risk of additive effects on immune function from a previously-used treatment. More than ever, neurologists treating MS should expect to see the unexpected. The solutions will come from real-world data of large groups of patients. The hope is that approaches based on ri…
…vailable. In the group who stopped treatment and never restarted, the most common DMTs at the time of quitting were Copaxone, Rebif, Avonex, Betaseron and Tecfidera. The treatments least commonly associated with permanent discontinuation were Tysabri and Aubagio. The survey also questioned MS patients about their use of other therapies. Overall, 34.1% said they took alternative/complementary therapies. A total of 64.9% said they take vitamin/miner…
…d in Lucas et al. Neurodegener Dis Manag 2015;5:413-424; free full text at www.futuremedicine.com/doi/pdf/10.2217/nmt.15.33). For example, vitamin D deficiency has been shown to prevent the development of experimental autoimmune encephalomyelitis (EAE), and vitamin D receptor knock-out mice do not develop EAE (reviewed in DeLuca & Plum. Photochem Photobiol Sci 2016; epublished December 2, 2016). In addition, an Australian case-control study found…
…he community (Raybould et al. PLoS One 2016;11:e0151081, free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC4786266/pdf/pone.0151081.pdfAbstract). Subjects were assessed at baseline and at 6 months. The primary outcome measure was change from baseline in ADAS-cog. Blood samples were obtained for C-reactive protein (CRP) inflammatory cytokines (tumour necrosis factor-alpha, interleukin-10), and antibodies to Porphyromonas gingivalis, a Gram-neg…