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K-index a predictor of T2 lesions in CIS, RIS

September 14, 2023

…. The K-index was also useful to predict clinical events in CIS. The study obtained blood and CSF from 146 CIS patients and 36 individuals with RIS. Median age for the two groups was 38 and 46 years, respectively. The K-index was calculated as the ratio of kappa free light chain in CSF and serum divided by the ratio of albumin in CSF and serum. A value >8.9 was considered to be positive based on the results of a previous study (Levraut M et al. Ne…

New ECTRIMS/EAN recommendations for vaccination in MS patients

September 5, 2023

…anti-CD20 therapy during pregnancy. Delay administering a live-attenuated vaccine to the infant until B cell counts have recovered. Click here to view the full text of the ECTRIMS/EAN recommendations: https://onlinelibrary.wiley.com/doi/10.1111/ene.15809 Correction: a previous version misattributed the recommendations to the AAN….

EAN HIGHLIGHTS 2023 – MONDAY, JULY 3 EDITION

July 3, 2023

…e activity Two fluid biomarkers, neurofilament-light chain (NfL) and kappa free light chain (kFLC), are useful individually and in combination to predict early disease activity, according to an analysis by the Vienna group (Hegen et al. EAN 2023;OPR-009). The study calculated the kFLC index (CSF kFLC/serum kFLC/albumin quotient) and the sNfL z-score adjusted for age and body-mass index for 86 patients with early MS. A total of 42% experienced a re…

NEUROLOGY NEWS IN BRIEF – JUNE 2023

June 27, 2023

…. Brain 2023;146:2275-2284). www.ncbi.nlm.nih.gov/pmc/articles/PMC10232284/pdf/awad024.pdf Biomarkers The Baltimore Longitudinal Study on Aging reports that plasma levels of glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) are elevated in cognitively unimpaired older individuals with certain personality traits (vulnerability to stress, anxiety and depression) (Terracciano et al. Neurobiol Aging 2023;128:65-73). www.sciencedirec…

Novel approach to MS therapeutics: anti-CD40L

June 21, 2023

…t Med 2000;6:114). This adverse effect was ultimately attributed to the Fc component of the MAbs, which formed anti-CD40L immune complexes that led to platelet aggregation and thrombosis. Second-generation MAbs were thus engineered without the Fc portion. Phase II data for the first of these second-generation agents, frexalimab (SAR441344), were presented at the Consortium of MS Clinics (CMSC) annual meeting (Vermersch et al. CMSC 2023;LB03). The…