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CLINICAL CASES IN MS – A case of worsening mobility during the pandemic

June 13, 2023

…ne but obtained no benefit. A year later, Michelle reported that she had become more sedentary during the pandemic. She said that was partly due to greater leg weakness, making it difficult for her to walk >500 metres unaided. She was fully vaccinated against COVID-19 and was seen in person. EDSS score was 3.5 (motor 3, cerebellar 2, sensory 2). Michelle said she had not experienced any relapses. MRI of the brain/spine was stable. At her most rece…

NfL – a guide to use in MS practice

May 31, 2023

…et al. Brain Commun 2022;4:fcac174; free full text at https://academic.oup.com/braincomms/article/4/4/fcac174/6628649). As a rough guide, the normal sNfL value is <10 pg/mL in healthy individuals aged <40 years, increasing 2-4% per year (Valentino 2021). NfL levels are inversely correlated with body-mass index and blood volume. NfL concentrations are higher in patients with kidney disease. NfL is subject to diurnal variation. Preliminary results i…

AAN update on anti-CD20 agents: long-term data

May 10, 2023

…/non-restricted/neurology/ectrims-2019/ECTRIMS_2019_OPERA_ORATORIO_Derfuss.pdf). The most common infections were urinary tract infections, cellulitis and pneumonia. Ofatumumab Ofatumumab long-term safety was analysed from the ALITHIOS study (N=1969), which comprised patients previously enrolled in four clinical trials (ASCLEPIOS I/II, APOLITOS and APLIOS). Four-year data were presented at the European Academy of Neurology meeting (Kappos et al. EA…

AAN 2023 HIGHLIGHTS – WEDNESDAY, APRIL 26

April 26, 2023

…2018;29:23-30). Intrathecal administration was associated with improved outcomes, according to the results of a later meta-analysis (Zhou et al. Stem Cells Int 2019;2019:8536785). The New York researchers have now completed a phase II study. Fifty-four PMS patients were stratified by EDSS score and phenotype (SPMS, PPMS) and randomized to autologous MSC-NP or placebo (Roche et al. AAN 2023;S16.005). Patients received six injections every two month…