…Hegen et al. Mult Scler 2023;29:182-195). One group has proposed kFLC analysis as the initial screening. An MS diagnosis could be made if the kFLC index >1; if <6.1, OCB testing would only then be performed (Monreal et al. Front Immunol 2023;14:1288169). The International Advisory Committee’s recommendations have not yet been made public so it is not known how the group will address these topics. Some details may be made available at the upcoming…

…e lesions. Rim-active lesions are a particularly destructive aspect of the compartmentalized inflammation seen in progressive MS. Indeed, the authors noted that rim-active lesion volume accounted for >50% of the change in sNfL level. Thus, it appears that microglial activation both within the lesion and in the surrounding tissue is a major contributor to neuroaxonal damage. While sNfL is most strongly associated with focal inflammatory activity, t…

…text at www.ncbi.nlm.nih.gov/pmc/articles/PMC10574823/pdf/NXI-2023-000383.pdf ). The study obtained serum NfL and GFAP levels before and after drug discontinuation in 78 MS patients. Patients were younger than those enrolled in recent discontinuation trials. Median age was 48.5 years, and median disease duration was 12.3 years. All participants had no clinical attacks or MRI activity for two years before and after drug discontinuation. Most patie…