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Update on CGRP inhibitors in migraine

May 18, 2018  

SPECIAL REPORT

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Calcitonin gene-related peptide (CGRP) inhibitors are emerging as an important class of agents for the prevention of episodic and chronic migraine (See Targeting CGRP in migraine, NeuroSens, March 28, 2018). Four monoclonal antibodies are currently in development: erenumab, a fully-human MAb targeting the CGRP receptor; and three humanized MAbs targeting the CGRP ligand (fremanezumab, eptinezumab, galcanezumab). Erenumab received FDA approval for the treatment of migraine this week. Read More

Update on oral cladribine – Effect on lymphocytes and safety data

May 9, 2018  

SPECIAL REPORT

New data were presented at the American Academy of Neurology annual meeting on the effect of oral cladribine on lymphocyte subsets in relapsing multiple sclerosis, providing new insights for evaluating the safety and efficacy of the drug. Oral cladribine is a cell-depleting disease-modifying drug, which was approved for use in Canada in November 2017. Read More

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‘Seduced by significance” – the p-value controversy

April 18, 2018  

The past decade has seen numerous criticisms of statistical methodology in biomedical research, fuelled in part by a ‘reproducibility crisis’ – the concern that many supposedly significant results cannot be replicated. The latest salvo was an editorial recently published in the Journal of the American Medical Association (Ioannidis JPA. JAMA 2018;319:1429-1430). Read More