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New dosing for glatiramer acetate

August 6, 2014

…dosing schedules with respect to ARR, EDSS, proportion of patients relapse-free and number of T1 and T2 lesions (Caon et al. AAN 2010; abstract S11.002). Twice-weekly dosing had the advantage of a lower incidence of lipoatrophy, injection site reactions and immediate post-injection systemic reactions, as expected with less frequent injections. Thus, while the new dosing of glatiramer acetate 40 mg may be administered three times per week without…

Deep-brain stimulation in PD: meta-analysis

July 23, 2014

…s, improvement in functionality during the off-medication phase, and reduction in medication dose. DBS had a moderate effect on QoL and motor signs and functionality during the on-medication phase. The authors noted that additional data are needed to determine the neurocognitive and psychiatric effects of DBS….

Managing epilepsy: are patients satisfied?

July 23, 2014

…nly nine studies used validated assessment instruments; 16 studies used non-validated instruments. Most studies were performed in the US or UK. Overall, neurologists and other healthcare providers earned high marks. The median proportion of patients satisfied with their epilepsy care was 86%, and 85% were satisfied with their clinician’s interpersonal skills. Lesser marks were earned for access to care (78%), communication (67%) and knowledge/tech…

APA 2014: New Research – Part 2

July 9, 2014

…antidepressant prescribed at hospital discharge (Warner et al. APA 2014; P1-13). Concomitant antidepressant use was associated with no benefit with respect to time to hospital readmission or mean time to readmission, even in patients with significant anxiety. In the subgroup with anxiety, patients were more likely to be readmitted if they received venlafaxine at discharge (hazard ratio 2.35 vs. no antidepressant; HR 5.38 vs. another antidepressant…

APA 2014: New Research – Part 1

June 25, 2014

…respectively. Also noteworthy was a separate study of ketamine in obsessive-compulsive disorder (OCD) (Rodriguez et al. APA 2014; NR4-01). The study randomized 10 patients to ketamine 0.5 mg/kg or sham infusion with crossover at 1 week. The responder rate was 50% at day 7; the rate was 40% at Day 14 for the subset initially randomized to active drug. Back to top Anxiety disorders A slow taper over 8 weeks appears to be effective in minimizing with…