Deep-brain stimulation in PD: meta-analysis


A new meta-analysis has concluded that deep-brain stimulation (DBS) is effective in the control of motor signs and for improving functionality and quality of life in patients with Parkinson’s disease (Perestelo-Perez et al. J Neurol 2014; epublished February 2, 2014). Data were analysed from six randomized controlled trials comparing DBS with medication versus medications alone (n=1184).

The outcome measures included motor function, time without dyskinesias, reduction in levodopa-equivalent dosing, neurocognitive and psychiatric effects, and effect on quality of life.

The analysis showed that DBS significantly improved PD symptoms, functionality and QoL. The effect size was greatest for the reduction in motor signs, improvement in functionality during the off-medication phase, and reduction in medication dose. DBS had a moderate effect on QoL and motor signs and functionality during the on-medication phase.

The authors noted that additional data are needed to determine the neurocognitive and psychiatric effects of DBS.

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