…as the limbic cortex (right insula, right anterior cingulate), the cortico-striato-thalamic loop (right superior frontal gyrus, right and left middle frontal gyri, right caudate, right ventral-anterior thalamus) and the attentional centres (right inferior parietal lobule, right and left angular gyri). In contrast to limbic activation, there was a noteworthy reduction in sensory cortex activity. Thus, sensory conversion symptoms appeared to be ass…

…ing recent reports of two cases of PML developing in patients who were anti-JCV Ab-negative (Carruthers et al. AAN 2014; abstract P2.247). Calculations were based on published serology data and a range of JCV serology test sensitivities/specificities. The model estimated that the probability of at least three PML cases in the false-negative group ranged from fair (11-17%) to high (89-95%). Following the two PML cases in Ab-negative patients, the U…