…rough some unknown mechanism (Kretzschmar et al. J Neuroimmunol 2014;268:58-63). Comment Dr. François Grand’Maison: The B-cell versus T-cell debate will rage until the immunopathology of MS has been unravelled. Let us not forget that the immunology of neuromyelitis optica, an inflammatory disease clinically similar to MS, is now understood. Optimism with respect to disentangling MS immunology is therefore warranted. However, the description of at…
…nt, REM behaviour disorder, orthostatic hypotension and sexual dysfunction, were more common in men. A separate review has examined the impact of gender on cognitive function and emotions (Heller et al. Aging Dis 2013;5:63-75; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3901615/pdf/ad-5-1-63.pdf). Overall, cognitive dysfunction appeared to be more common in males, although the authors noted that test results are inconsistent. Males with…
A meta-analysis has concluded that amyloid-beta1-42 in CSF is useful for discriminating Alzheimer’s disease from controls (Rosa et al. J Alzheimers Dis 2014; epublished January 21, 2014). The review included prospective, retrospective, case-control and cross-sectional studies. Of 804 citations identified, 41 were included in the analysis. The meta-analysis showed that the diagnostic odds ratio for amyloid-beta1-42 was 28.9. Sensitivity was 84.3%;…
…925; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3709884/pdf/JME-16-917.pdf). These clinical benefits of relapse reduction and fewer in-patient stays may be attributable in part to the more stable drug levels achievable with LAIs and to improved rates of treatment adherence and persistence. In the long-term open-label extension of aripiprazole OM phase III studies, 79.4% of patients remained on treatment at one year, with few patients s…
…rols. Both the amplitude of the melatonin rhythm and the 24-hour area-under-the-curve (AUC) were significantly lower in PD subjects versus controls. Patients with excessive daytime sleepiness (ESS score >10) had a significantly lower amplitude of melatonin rhythm and 24-hour melatonin AUC. Melatonin circadian rhythm was not related to levodopa-equivalent dose or UPDRS scores. The authors suggested that interventions that target circadian rhythm, s…