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ECTRIMS Poster Picks – Friday, September 13

…lizumab and NEDA (P1348); cognition and Dimethyl fumarate (P1396); DMF long-term data (P1397) Network meta-analysis: P1394 Recommendations: Initial DMT choice (P1351) Emerging treatments: Evobrutinib (P1358); Biotin (P1399) Interesting items: • Placebo cohorts (P1140) • Cognitive relapses (P1155) • Driving ability (P1308) • Vitamin D and NfL (P1347) • Beyond NEDA (P1415) Canadian research: Prodrome (P1124; P1153); Comparing DMTs (P1125); ADEM (P11…

ECTRIMS 2019 DAILY REPORT – THURSDAY EDITION

…Relapse risk was reduced 55% with active treatment. The proportion relapse-free at week 96 was 72.1% with satralizumab versus 51.2% with placebo. Back to top Cladribine and time to SPMS A post-hoc analysis of the CLARITY trial found that the proportion of patients who progressed to SPMS was 54% lower with cladribine 3.5 mg compared to placebo (6.7% vs. 13.5%) (Vermersch P. ECTRIMS 2019; abstract P385). A proxy definition of SPMS was used since SP…

ECTRIMS Poster Picks – Thursday, September 12

…ngitudinal (P946) Phase III data: Siponimod (P750); Alemtuzumab (P974) Long-term data: Natalizumab (P1013); Fingolimod (P1014); Ocrelizumab (P1015); Beta-interferon-1b (P1016) Anti-CD20 and immunoglobulins: P979, P1010 NEDA and MEDA: loss of MEDA (P1030); prognostic value (P1050); DMTs (P1070) Biotin: P1002, P1003 Network meta-analysis: P981 Interesting items: • DMT outcomes (P812) • Use of gadolinium (P901) • PML and ocrelizumab (P970) • Nocebo e…

ECTRIMS Poster Picks – Wednesday, September 11

…Phase III data: Siponimod (P382, P435); Cladribine (P385, P624, P633) Long-term data: Alemtuzumab (P645, P651); Teriflunomide (P646); Dimethyl fumarate (P647); Glatiramer acetate (P656) MSBase studies: MSSS and disability (P434); Cladribine (P661) Interesting items: • Prevalence of hypogammaglobulinemia (P407) • Patient-determined disease steps (P433) • Siponimod vs. Fingolimod (P622) • Ocrelizumab safety (P648) • Hepatitis B vaccination (P671) C…

Progressive MS trials – design and interpretation

…4; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC6356776/pdf/cells-08-00024.pdf). This suggestion of a putative neuroprotective effect is supported by the early and significant reduction in brain atrophy reported with siponimod in EXPAND. Additional data on the effects of siponimod in the CNS and on grey-matter atrophy will be presented at ECTRIMS 2019 (abstracts P382, P512, P844, P1008 and P1376). Other potential neuroprotective strategi…