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Effect of NaCl on pathogenic Th17 cells

REPORT FROM THE AMERICAN ACADEMY OF NEUROLOGY (AAN) ANNUAL MEETING, SAN DIEGO, CA, MARCH 16-23, 2013 -High sodium chloride levels promote the differentiation of proinflammatory Th17 cells that are highly pathogenic, according to the preliminary results of an in vitro study in naïve human CD4+ cells (Kleinewietfeld et al. AAN 2013; abstract S11.004). Subscribe to read more It takes 30 seconds or login using your email address Please enter the emai…

Application to FDA for first-line natalizumab

Biogen Idec has applied to the U.S. Food & Drug Administration and the European Medicines Agency to extend the indication for Tysabri (natalizumab) to include first-line use in MS. The first-line indication would be for patients with relapsing MS who had tested negative for JC virus antibodies. At present, the indication for use of natalizumab is as a second-line treatment option for patients who fail prior therapy or have rapidly evolving MS. Su…

Vitamin D and MS: conflicting evidence of clinical benefit

…There are now several studies indicating that vitamin D status affects selected clinical endpoints in MS, but evidence for treatment benefits has been mixed. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

Pilot study of GSK-3 drug tested in AD

…A pilot phase IIa study (NCT00948259) has reported promising effects of tideglusib, a novel inhibitor of glycogen synthase-3 (GSK-3), in 30 patients with mild to moderate Alzheimer’s disease (Del Ser et al. J Alzheimers Dis 2013;33:205-215). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

RIS: what are the risk factors for CIS/MS?

…There has been little information on the natural history of radiologically isolated syndrome (RIS) since it was first described in 2009 (Okuda et al. Neurology 2009;72:800-805). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…