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AAN 2023 HIGHLIGHTS – MONDAY, APRIL 24

April 24, 2023

…reached EDSS ≥4.0. The prediction of progressive MS was improved with the combination of serum neurofilament-light chain (sNfL) and glial fibrillary acid protein in CSF (cGFAP) compared to either measure alone. NfL generally reflects neuroaxonal damage due to disease activity; GFAP is a marker of astrocyte activation and neurodegeneration. Patients in the highest quintiles of both measures had a 5.5-fold higher risk of reaching EDSS ≥4.0 and a 3….

Putting biomarkers into practice

March 8, 2023

…al NfL measures in individual patients (see RCV tool at BMJ 2020;368:m149: www.bmj.com/content/368/bmj.m149/rr-8). Serum NfL was obtained every three months in 58 MS patients over one year. In comparing patients with and without MRI lesions, median RCV was 57 and 92, respectively. An RCV using a cut-off of >76 was predictive of new MRI lesions (sensitivity 60%, specificity 75%). A 10-unit increase in RCV was associated with a 30% increase in the o…

Putting shared decision-making into practice

February 16, 2023

…d to feeling uninformed, as well as a positive effect on physician-patient communications. Use of patient-reported outcome measures (PROMs) PROMs can provide a more holistic view of patients’ general functioning and can be employed in the ongoing assessment of treatment effectiveness and tolerability (Rieckmann et al. Mult Scler Relat Disord 2015;4:202-218). While PROMs can enhance SDM by providing data that may be more relevant to the patient, th…

MS Awards 2022 – Oddities and Observations

December 9, 2022

…s/territories, and failed to follow-up with travellers to ensure they were complying with quarantine orders (www.oag-bvg.gc.ca/internet/English/parl_oag_202103_03_e_43785.html). Still, it could have been worse, said Dr. Theresa Tam and colleagues in PHA’s counterfactual analysis of the pandemic (Ogden et al. Can Commun Dis Rep 2022;48):292-302; see link below). The authors noted that the consequences of unrestrained SARS-CoV-2 spread were dire – l…