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ECTRIMS 2024 slide resource

…ptember 2024 Please note that the NeuroSens ECTRIMS 2024 Highlights slide resource, developed in collaboration with Dr. Daniel Selchen, BARLO MS Centre, Toronto, will be available as of October 10th, on request only. Make your request now by completing the online form. Industry members can also use this form to request to sponsor a NeuroSens post-ECTRIMS event (in-person or virtual). For more information, contact us at info@neuro-sens.com. In the…

Does MS burn out?

…lished paper on the topic used the descriptor ‘benign/burnt-out MS’, which compounded one controversial term with another (McFaul et al. Neurol Neuroimmunol Neuroinflamm 2021;8:e960). The study was a health database analysis, so the term was less about clinical measures than about checkboxes; the goal was to identify people who could safely stop their disease-modifying therapy (DMT). As such, benign/burned-out MS was defined as an RRMS patient wit…

Geographic determinants of health: location, location

…nadian-virtual-care-priorities-covid-19/enhancing-access-principle-based-recommendations-equity/based-recommendations-equity-en.pdf). For example, a NARCOMS survey found that telehealth video visits were less common among disadvantaged groups, such as the elderly and those with greater impairments (Marrie et al. Neurol Clin Pract 2022;12:223-233). Telephone contact can be made in rural areas where videoconferencing is unavailable but generally pro…

New developments in epilepsy: focus on cenobamate

…se of 400 mg. As cenobamate is added to the ASM regimen, it is generally recommended to adjust the dosing of the concomitant ASMs to minimize pharmacokinetic and/or pharmacodynamic interactions. Cenobamate inhibits the P450 2C19 isoenzyme that metabolizes ASMs such as phenytoin, clobazam and phenobarbital. This interaction increases the plasma concentration of phenytoin, phenobarbital and the active metabolite of clobazam. As a result, it is recom

The year in review – 2023

…failed to meet its primary endpoint in its two EVOLUTION phase III trials (www.emdgroup.com/en/news/evobrutinib-phase-lll.html). The annualized relapse rate for evobrutinib in the two studies (0.11, 0.15) was similar to what was seen with teriflunomide (0.11, 0.14). Evobrutinib performed as expected: the unadjusted ARR was the same in the phase II trial (0.11 vs. 0.14 for DMF) (Montalban et al. N Engl J Med 2019;380:2406-2417) and the same (0.11)…