Bivalent COVID booster approved in Canada
September 16, 2022…That booster (mRNA-1273.222), which the FDA is calling an updated booster, combines the original vaccine with Omicron subvariant BA.4/BA.5 spike proteins. Due to an absence of data, authorization was based on the safety results of the mRNA-1273.214 study cited above and an unpublished preclinical study, which reported little additional benefit with the updated booster compared to the mRNA-1273.214 booster even against the BA.5 subvariant (Scheaffe…