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Biomarkers after stopping treatment may identify at-risk MS patients

November 30, 2023

…et al. Neurol Neuroimmunol Neuroinflamm 2023;10:e200167; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC10574823/pdf/NXI-2023-000383.pdf ). The study obtained serum NfL and GFAP levels before and after drug discontinuation in 78 MS patients. Patients were younger than those enrolled in recent discontinuation trials. Median age was 48.5 years, and median disease duration was 12.3 years. All participants had no clinical attacks or MRI activi…

New ECTRIMS/EAN recommendations for vaccination in MS patients

September 5, 2023

…anti-CD20 therapy during pregnancy. Delay administering a live-attenuated vaccine to the infant until B cell counts have recovered. Click here to view the full text of the ECTRIMS/EAN recommendations: https://onlinelibrary.wiley.com/doi/10.1111/ene.15809 Correction: a previous version misattributed the recommendations to the AAN….

NEUROLOGY NEWS IN BRIEF – JUNE 2023

June 27, 2023

…xiety and depression) (Terracciano et al. Neurobiol Aging 2023;128:65-73). www.sciencedirect.com/science/article/pii/S0197458023000787?via%3Dihub A Norwegian group has reported that a panel of seven inflammatory biomarkers was able to differentiate Parkinson’s disease from controls. A separate panel of four inflammatory biomarkers was useful to differentiate Alzheimer’s disease from dementia with Lewy bodies and PD (Pedersen et al. Neurol Neuroimm…

NfL – a guide to use in MS practice

May 31, 2023

…et al. Brain Commun 2022;4:fcac174; free full text at https://academic.oup.com/braincomms/article/4/4/fcac174/6628649). As a rough guide, the normal sNfL value is <10 pg/mL in healthy individuals aged <40 years, increasing 2-4% per year (Valentino 2021). NfL levels are inversely correlated with body-mass index and blood volume. NfL concentrations are higher in patients with kidney disease. NfL is subject to diurnal variation. Preliminary results i…

AAN update on anti-CD20 agents: long-term data

May 10, 2023

…view, which found that ofatumumab may have a more favourable effect on IgG compared to other B cell-depleting agents (Saidha et al. Neurol Sci 2023;44:1515–1532. Free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC9843103/pdf/10072_2022_Article_6582.pdf). The authors hypothesized that differing effects on IgG may be due to dosing, route of administration and/or epitope binding. The rate of malignancy in ALITHIOS at four years was unchanged at 0…