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Facebook: friend or foe of psychiatry?

May 14, 2014

…4X-13-268.pdf). Reins et al. BMC Psychiatry 2013;13:318, free full text at www.biomedcentral.com/content/pdf/1471-244X-13-318.pdf). The latest alternative to face time is Facebook. A new study has examined whether joining Facebook – and specifically “friending” the psychiatrist – is beneficial in patients with treatment-resistant depression (Mota Pereira J. Scientific World J 2014;2014:892048; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PM…

The high impact of neurological and psychiatric disorders: the Global Burden of Disease Study

May 14, 2014

…s major depression (Charlson et al. BMC Med 2013;11:250; free full text at www.biomedcentral.com/content/pdf/1741-7015-11-250.pdf). Depressive disorders are the leading contributor to disability-adjusted life years (DALY), and the second-leading cause of YLD (Ferrari et al. PLoS Med 2013;10:e1001547; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3818162/pdf/pmed.1001547.pdf). The greatest burden is seen in depressive disorders, followed b…

Traumatic brain injury in sports a focus of annual meeting

May 2, 2014

…ofessional athletes. A review of the hockey literature found that the most common CNS injuries were concussion (0.2-6.6 per 1000 player-hours), and spinal cord injuries (5.0 per 1000 player-hours) (Toy et al. AAN 2014; abstract P5.343). An analysis of blood biomarkers in 28 Swedish Hockey League players reported that levels of total-tau (T-tau, a marker of axonal injury) and S100 calcium binding B (S-100B, a marker of astroglial injury) were eleva…

Alemtuzumab receives Health Canada approval

April 23, 2014

…monitoring for autoimmune thyroid disease is advised. Alemtuzumab is not recommended in women planning to become pregnant or during breastfeeding. Approval of alemtuzumab (Lemtrada) was based on the results of two phase III studies (CARE-MS I, CARE-MS II) and a phase II study (CAMMS223). In CARE-MS I, alemtuzumab and subcutaneous interferon-beta-1a 44 mcg three times/week were compared in 563 treatment-naïve RRMS patients (Cohen et al. Lancet 2012…

Fingolimod: impact on beta-amyloid neurotoxicity?

March 19, 2014

…elination (Miron et al. Am J Pathol 2010;176:2682-2694). Other non-immunological effects of fingolimod in the CNS may include downregulation of S1P1 signalling from astrocytes, which reduces astrogliosis and clinical severity in EAE (Choi et al. PNAS USA 2011;108:751-756; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3021041/pdf/pnas.201014154.pdf) For a recent review of S1P1 signalling in the CNS see Groves et al. J Neurol Sci 2013;328:9…