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Amyloid-beta in CSF: meta-analysis of accuracy in diagnosis

August 20, 2014

…l. Transl Neurosci 2013;4:10.2478; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3873720/). They further noted that ELISA kits for amyloid-beta1-42 (and for t-tau) produced by different manufacturers will not have the same results and should not be used interchangeably. Comment Dr. Yves Bacher: Biomarkers will probably become more and more useful in the case of early-onset dementia, strong familial history, MCI management and atypical pre…

Long-acting injectable aripiprazole approved in Canada

August 13, 2014

…zation of LAI continues despite the recently published Canadian Clinical Recommendations on LAI use, recommending that LAIs be positioned earlier in the course of treatment (Malla et al. Can J Psychiatry 2013). There are multiple reasons for the underutilization of LAIs. Some are patient-related, such as suspicion about injected drugs, concerns about a lack of personal control, etc. Some are clinician-related, such as a lack of staff support, the…

Sleep disorder in PD: a role for circadian rhythm disturbance?

August 6, 2014

…eta-analysis of modafinil found that there was insufficient evidence for recommending the drug for PD patients with excessive daytime sleepiness (Sheng et al. PLoS One 2013;8:e81802; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3849275/pdf/pone.0081802.pdf). A novel suggestion is that disturbances to circadian rhythm may play a role in sleep-wake disturbances in PD. To investigate this, a cross-sectional study monitored serum melatonin l…

APA 2014: New Research – Part 1

June 25, 2014

…7.2% with vortioxetine 15 mg and 20 mg versus 15.8% with placebo. The most common adverse effects were nausea, headache, diarrhea, dry mouth, dizziness and excessive sweating. A second 8-week study comparing vortioxetine 15 mg or 20 mg/day with duloxetine 60 mg/day or placebo in 614 MDD patients reported similar results (Mahableshwarkar et al. APA 2014; NR9-01). The least-squares mean change from baseline in MADRS total score was -14.30 and -15.57…

MS patient website tops 70,000 visits

June 3, 2014

…s in MS research, and to refer their MS patients to MSology to learn more about their disease. To access the site, go to www.MSology.com….