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MS treatment: What is Plan B?

…-diagnosis, when treatments may have their greatest impact on long-term outcomes in RRMS. Comment: Dr. Paul Giacomini, MD, FRCPC, Associate Director, MS Clinic, Montreal Neurological Hospital and Institute, Assistant Professor, Department of Neurology and Neurosurgery, McGill University, Montréal, Québec: The advent of new oral therapies, coupled with a greater understanding of MS pathophysiology, is certainly reshaping the way neurologists and th…

Seizure prophylaxis following traumatic brain injury

…Trauma Foundation. J Neurotrauma 2007;24(suppl 1); free full supplement at www.braintrauma.org/pdf/protected/Guidelines_Management_2007w_bookmarks.pdf). A review of antiepileptics for TBI recommends phenytoin since it has been most extensively studied (Torbic et al. Am J Health Syst Pharm 2013;70:759-766). Other agents (e.g. phenobarbital, valproate, carbamazepine) have not been researched to the same degree and are not generally preferred over ph…

Inappropriate prescribing common in AD patients

…edication (PIM) use in 684 patients with mild-to-moderate AD living in the community (Montastruc et al. Eur J Clin Pharmacol 2013;69:1589-1597). Overall, 46.8% of subjects had received at least one PIM. The most common PIMs were cerebral vasodilators (24% of all prescriptions), atropinic drugs (17%) and long half-life benzodiazepines (8.5%). In 16% of cases, atropinic agents were given in conjunction with cholinesterase inhibitors. At risk of PIMs…

New review of PD pathophysiology

…ers may find useful for teaching purposes. Free full text is available at: www.frontiersin.org/Neurodegeneration/10.3389/fneur.2013.00033/abstract. Comment Dr. Michel Panisset: Although the cause for Parkinson’s disease is still unknown, new data are helping to open up new avenues for investigations, e.g. gastrointestinal involvement, increased absorption and mesenteric plexus Lewy bodies, and the prion-like behavior of alpha-synuclein. Finding th…

Guidelines on managing bipolar disorder: CANMAT 2013 update

The Canadian Network for Mood and Anxiety Disorders (CANMAT) has produced an update of its guidelines for the management of patients with bipolar disorder (Yatham et al. Bipolar Disord 2013;15:1-44). The guidelines were produced in conjunction with the International Society for Bipolar Disorders. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Cont…