…nd EDSS score at last visit (Ramanujam et al. medRxiv 2020.07.09.20149674; free full text at www.medrxiv.org/content/10.1101/2020.07.09.20149674v1.full.pdf). For example, the probability of SPMS was 93% for any patient with EDSS >6; 76% if EDSS >4.5 in a patient aged >45 years (38% if younger than 45 years); and so on. Applying this algorithm to five MS registries in Europe increased the proportion of patients diagnosed as SPMS from 17% to 31% (Hi…

…onth 3. The results indicate that there is a therapeutic effect before the complete two-year course of cladribine is completed. Sequencing has effects on Ig Concerns have been raised about the possible effects on immune competence of sequential disease-modifying therapies. A study compared whole-blood samples from 133 RRMS patients (aged 17-66 years) versus patients with other neurological conditions and healthy controls (Keiner et al. ECTRIMS 202…