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The overlooked role of T cells in the antiviral response

July 21, 2020

…ine within two months of disease onset (Seow et al. medRxiv preprint; free download at www.medrxiv.org/content/10.1101/2020.07.09.20148429v1.full.pdf). This has raised concerns about whether a COVID-19 vaccine would confer long-lasting immunity. However, the emphasis on B cells overlooks the importance of CD4+ and CD8+ T cells in the early immune response to CoV-2. A robust T cell response appears to be important in limiting disease severity in ot…

Neurofilament-light – Update from EAN

July 14, 2020

…;56:102807; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC7251380/pdf/main.pdf). Baseline NfL levels were 12.5 pg/mL in RRMS and 10.1 pg/mL in CIS (9.1 pg/mL in CIS patients according to McDonald 2017 criteria). Baseline NfL levels were higher in patients with >9 T2 lesions, Gd+ lesions or recent relapses. NfL was only weakly correlated with EDSS score or the presence of ring-enhancing lesions. Modelling to discriminate CIS from MS showed…

Update on B cells in MS pathophysiology

June 29, 2020

…atment-free period (Baker et al. Mult Scler Relat Disord 2020; preprint at www.medrxiv.org/content/10.1101/2020.01.09.20016774v1.full.pdf). This has prompted the suggestion that the current six-monthly dose schedule may be too frequent (Baker et al. EBioMedicine 2017;16:41-50), or that a flexible dose schedule may be beneficial (Avasarala et al. Drug Target Insights 2017;11:1177392817737515). Body-mass index may also influence B cell kinetics, wit…