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More controversy for AstraZeneca COVID-19 vaccine

…it plans to release the results from its primary analysis later this week (www.astrazeneca.com/content/astraz/media-centre/press-releases/2021/update-following-statement-by-niaid-on-azd1222-us-phase-iii-trial-data.html). A further issue that has plagued the AstraZeneca vaccine is the link to rare thrombotic complications. To date, the European Medicines Agency has recorded 18 cases of cerebral venous sinus thrombosis (CVST) in approximately 20 mil…

Vaccines and thrombotic complications

…r pro-coagulant effects on platelets (Bollmann A. Br Med J, 16 March 2021. www.bmj.com/content/372/bmj.n699/rapid-responses). At present, it is not known if thrombocytopenia/thromboembolism is associated with COVID-19 vaccination, or if the incidence of these complications is uniquely higher with the AstraZeneca vaccine. It also remains to be determined if pre-existing thrombocytopenia, as seen in some treated multiple sclerosis patients, increase…

SARS-CoV-2 variants

…Summarizes recent data on the UK (B.1.1.7), Brazil (P.1) and South Africa (B.1.351) variants. Also included are the number of variant cases reported in Canada and the U.S. as of March 9, 2021. 9 slides Download slide deck…

COVID-19 vaccination and pregnancy

…do not contain live virus and viral mRNA does not enter host cell nuclei (www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html). The American College of Obstetricians and Gynecologists recommends that COVID-19 vaccines should not be withheld from pregnant or lactating women (www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/12/vaccinating-pregnant-and-lactating-patients-against-covid-19). The Academy of…