…(MTR), a marker of myelin density, in normal-appearing white matter, with complete suppression of MTR decline at 24 months (Arnold et al. EAN 2020; EPR1147). Treatment was also associated with improvement in MTR recovery in new lesions; the authors noted that this finding was consistent with promotion of remyelination. A separate analysis reported significant reductions with siponimod versus placebo in cortical grey-matter atrophy and thalamic at…

…//www.cambridge.org/core/services/aop-cambridge-core/content/view/6F71BA9F915D7AC1228BBB52EF3B8AD7/S0317167120000669a.pdf/treatment_optimization_in_multiple_sclerosis_canadian_ms_working_group_recommendations.pdf). (Full disclosure: NeuroSens staff provided logistic and editorial support during the development of the treatment optimization recommendations.)…