…ow being investigated. Early use of high-efficacy DMTs may also permit drug-free intervals (as with cladribine) or de-escalation to a less intensive maintenance regimen. Such adjustments may serve to facilitate the shift to the earlier use of high-efficacy DMTs as the new standard of care. Survey 1. In what RRMS patients would you generally initiate treatment with a high-efficacy DMT? I would not initiate treatment with a HE DMT Only patients with…

…ections or other complications when administered prior to aHSCT. The study examined data for 104 MS patients (mean age 30.8 years) who had received a DMT <6 months prior to undergoing aHSCT in the period 2011-2021. Mean duration of MS was 5.8 years. Median EDSS score at baseline was 3.0 (range 0-6.5). The mean number of prior DMTs was 2.1; 11.5% patients were previously untreated (aHSCT is a first-line option in Sweden) and 16.3% had received >4 D…