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CLINICAL CASES IN MS – AN OLDER PATIENT WITH STABLE DISEASE

February 9, 2023

…self-injecting and was switched to dimethyl fumarate. She has been relapse-free for the past five years. An MRI in 2019 showed two new lesions but MRI has been stable ever since. EDSS has been stable for five years; in November 2022, EDSS score was 2.5 (motor 2, cerebellar 2). The survey is now closed. We received 34 responses. See below for a summary of the answers you provided. Question 1: Do you agree that there is no evidence of progression?…

MS Awards 2022 – Oddities and Observations

December 9, 2022

…ada.ca/content/dam/phac-aspc/documents/services/reports-publications/canada-communicable-disease-report-ccdr/monthly-issue/2022-48/issue-7-8-july-august-2022/ccdrv48i78a01-eng.pdf). Persistence Prize This year saw the 27-year follow-up of the Copolymer-1 trial (Ford et al. Mult Scler 2022;28:1729-1743); median duration of drug exposure was 9.8 years. The completion rate for the long-term extension was 20.7%, which was lower than the completion rat…

Effectiveness of COVID boosters in MS: an update

November 30, 2022

…oster injection was 34%. Seroconversion rates were 17% of patients on ocrelizumab, 47% for those on fingolimod, and 100% for patients on all other DMTs. An additional 7% seroconverted after a second booster injection. There was an anti-CoV-2 T cell response in 65% of patients; a T cell response was not evident in fingolimod-treated patients. The efficacy of the bivalent boosters has not been reported (Bivalent COVID booster approved in Canada, Neu…

2022 – the year in review

November 29, 2022

…2022; P345). The ALITHIOS study also reported that COVID was generally mild-to-moderate in severity among ofatumumab-treated patients who were partially or fully vaccinated (Cross et al. Neurol Ther 2022;11:741-758).The improved vaccine response and lower infection risk may be attributable in part to the modest effect of ofatumumab on immunoglobulins. A long-term safety study showed that IgG levels remained stable and IgM levels remained above the…

CLINICAL CASES IN MS – A STABLE PATIENT WITH RISING JCV INDEX

November 17, 2022

…itis. Six months later he experienced a myelopathic episode. MRI-brain and -C-spine revealed a moderate disease burden of seven T2 lesions and one Gd+ lesion. He was started on interferon-beta-1a s.c. in 2013. He was clinically stable for two years but showed some ongoing MRI activity. EDSS was 2.5 (vision 2, motor 2, sensory 1). In 2016, he experienced another myelopathic episode. EDSS post-recovery was 3.0 (vision 2, motor 2, sensory 2, bladder…