SPMS pathogenesis and treatment
November 14, 2022…on in whole-brain atrophy with siponimod versus placebo was 49% at year 1 (-0.23 vs. -0.45), and 31% at year 2 (-0.62 vs. -0.92). Relative reduction in cortical GM volume loss with siponimod versus placebo was 102% at 1 year (+0.01 vs. -0.60), and 63% at 2 years (-0.39 vs. -1.04). There were also significant reductions in thalamic volume loss at both time points (50% year 1, 42% at year 2). Moreover, siponimod improved brain tissue integrity and r…