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EAN 2022 HIGHLIGHTS – WEDNESDAY, JUNE 29 EDITION

June 29, 2022

…tumumab had an immune response within one week of full vaccination. The CoV-2-specific T cell response was unaffected by treatment. The level of neutralizing antibodies was lower than was seen in controls but 50% were seropositive. The study is ongoing. Delayed time to wheelchair with siponimod An analysis of the EXPAND trial estimated that siponimod reduces the risk of reaching EDSS >7.0 by 40% versus placebo in patients with SPMS (Vermersch et a…

EAN 2022 HIGHLIGHTS – TUESDAY, JUNE 28 EDITION

June 28, 2022

…an EDSS score was 2.5 for RRMS, 6.5 for SPMS and 6.0 for PPMS. Mean relapse-free time was 13 years. A total of 58% were on a DMT. There was no difference in relapse-free time or EDSS score between groups with or without a DMT. Ocrelizumab EID Two studies have examined the clinical impact of delaying ocrelizumab infusions during the pandemic. The first study reported that extended-interval dosing (EID, defined as a dosing interval >7 months) was no…

Bivalent boosters in development for COVID-19

June 21, 2022

…erna boosters, mRNA-1273.211, contains equal mRNA amounts of ancestral SARS-CoV-2 (Wuhan isolate) and Beta variant spike proteins. The phase II/III trial enrolled 896 adult participants (mean age 50.7 years) from the COVE trial, in which all subjects received two doses of the Moderna vaccine (Baden et al. N Engl J Med 2021;384:403-416). The bivalent booster (50 or 100 µg) was administered at least 6 months (mean 264-294 days) after the original tw…

CLINICAL CASES IN MS – CASE 5: A CLINICALLY STABLE PATIENT PLANNING A PREGNANCY

June 15, 2022

…ladribine dosing (15%). 3. Assuming all vaccines and TB skin testing are up-to-date, what testing is needed when transitioning from fingolimod to another higher efficacy agent (e.g. natalizumab, ocrelizumab, cladribine)? A majority (55%) would obtain a CBC with differential, MR head, and serum JCV antibody testing with index. Some respondents opted for CBC with differential, MR head, CSF for JCV (15%); CBC with differential and MR head with gadoli…

How much B cell suppression is needed in MS?

May 30, 2022

…Includes a comparison of anti-CD20 therapies (rituximab, ocrelizumab, ofatumumab), depth and duration of B cell suppression, time to B cell reconstitution, and current data on reduced-dose regimens, extended-interval dosing and personalized dosing. 14 slides Download slide deck…