Neurology

Is all MS progressive?

 

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A recent debate in the literature addressed the question of whether all cases of multiple sclerosis are progressive. The discussion highlighted some of the challenges of diagnosing secondary-progressive MS (SPMS) and the limitations of viewing the MS disease process as distinct phenotypes. Read More

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MS trials: Do you SCUBA?*

 

[*seriously consider using bothersome acronyms]

Two decades ago, an alarm was sounded on the exploding use of acronyms in clinical trials. The worst offender at the time was cardiology, which boasted 16 separate trials called HEART (Fred et al. Tex Heart Inst J 2003;30:255-257). With acronyms on the radar, other specialties soon joined in. Within a few years, the estimated prevalence of trial acronyms was 15% (40% in cardiology) (Pottegard et al. Br Med J 2014;349:g7092). For some it filled a GAP (Greater Acceptance by Publishers): studies with good acronyms were more likely to be cited by other researchers (Stanbrook et al. N Engl J Med 2006;355:101-2). Read More

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