Secondary-progressive MS: conceptual and practical challenges


Part 2

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Secondary-progressive multiple sclerosis (SPMS) is the onset of gradual worsening of disability following a relapsing-remitting course that may or may not be accompanied by relapses. There are no clear-cut demarcations (imaging, pathologic, immunologic) between the RRMS and SPMS phases, so diagnosis is generally made retrospectively.

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