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Augmentation in treatment-resistant depression: meta-analyses

…of all adult depression visits. This increased to 12.5% for the period 2009-2010. An antipsychotic was five-fold more likely to be prescribed by a psychiatrist compared to other health professionals. Patients with a diagnosis of major depressive disorder were more likely to receive an antipsychotic compared to those with other depressive disorders (adjusted OR 1.49). Antipsychotics were less likely to be prescribed in patients older than age 65 ye…

Combining drug and psychotherapy more effective for depression, anxiety

…one in managing patients with major depression, panic disorder or obsessive-compulsive disorder (Cuijpers et al. World Psychiatry 2014;13:56-67; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC3918025/pdf/wps0013-0056.pdf). The analysis included 52 studies (n=3,623): 22 studies of major depression, 5 of dysthymia, 5 of mixed mood disorders, 10 of panic disorder, 4 of OCD (including 1 with depression), 4 of social anxiety disorder (SAD), 2 o…

New data for daclizumab in MS

…h daclizumab 150 mg (0.21) and 300 mg (0.23) versus placebo (0.46). Relapse-free rates were 81%, 80% and 64%, respectively. There was one death (psoas abscess) in the daclizumab 150 mg group. For the SELECTION extension study, placebo patients were randomized to one of two doses of daclizumab q4weeks for 52 weeks (Giovannoni et al. Lancet Neurol 2014;13:472-481). Patients on active treatment continued in their group assignment but were randomized…

Environmental factors in MS: Air and vitamin D

REPORT FROM THE ACTRIMS-ECTRIMS – BOSTON, MA, SEPTEMBER 10-13, 2014 – Few studies have examined the potential impact of ambient air quality and airborne particulates on multiple sclerosis. A decade ago, a study in Finland suggested that the frequency of MS relapses was higher with increasing levels of inhaled particulates (Oikonen et al. Neuroepidemiology 2003;22:95-99). A study at UCLA now suggests that exposure to air pollution may be associate…

Gut microbiome and MS pathogenesis

…by inducing the conversion of naïve CD4+ T cells to Tregs that produced IL-10 (Ochoa-Reparaz et al. Mucosal Immunol 2010;3:487-495). This work was updated at ACTRIMS-ECTRIMS with new data (Kasper et al. ECTRIMS 2014; abstract P611). An in vitro study of human peripheral blood mononuclear cells (PBMC) exposed to PSA showed a dose-dependent increase in Tregs producing IL-10 and a corresponding decrease in TNF-alpha. This is the first study to show…