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ADAPT trial update: NSAIDs in AD

December 14, 2011

…5: 93-104; free full text at www.ncbi.nlm.nih.gov/pmc/articles/PMC2866447/pdf/nihms185404.pdf). The trial was suspended in 2004 following the finding from the Adenoma Prevention with Celecoxib (APC) trial of an increased cardiovascular risk with celecoxib (Solomon et al. N Engl J Med 2005; 352: 1071-1080; free full text at www.nejm.org/doi/full/10.1056/NEJMoa050405). Subscribe to read more It takes 30 seconds or login using your email address Ple…

CONFIRM – Second phase III trial results for BG-12

November 30, 2011

…OF THE EUROPEAN COMMITTEE FOR TREATMENT AND RESEARCH IN MULTIPLE SCLEROSIS (ECTRIMS) – AMSTERDAM, THE NETHERLANDS, OCTOBER 19-22, 2011 – Just days after ECTRIMS, top-line results from the second of two phase III trials of BG-12 were announced in a press release (www.biogenidec.com/PRESS_RELEASE_DETAILS.aspx?ID=5981&ReqId=1621631) and in a webcast to investors (www.biogenidec.com/investors.aspx?ID=5494). Subscribe to read more It takes 30 seconds o…

No benefit with simvastatin add-on therapy in MS

November 9, 2011

…The most recent results from the SIMCOMBIN trial of combined beta-interferon and simvastatin, an HMG CoA reductase inhibitor, indicate that there is no beneficial effect with add-on therapy (Sorensen et al. Lancet Neurol 2011; 10: 691-701). Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…

CNS drug development: a pipeline of problems

November 9, 2011

….S. and Europe. Subscribe to read more It takes 30 seconds or login using your email address Please enter the email address that you registered the newsletter with Continue…